Patagioenas picazuro are discreet around their nests but can display defensive behaviours, such as loud wing-beating or pretending to be injured to distract predators. Both the male and female help build the nest and raise the chicks.

While one nest was found in a forested area, most were located in open environments, such as farmland or urban spaces. The species adapts well to human-altered landscapes and often uses exotic trees for nesting.

Nests were observed in Arcos, Minas Gerais (21 nests) and Caseara, Tocantins (1 nest).

Nesting occurs almost year-round, with some pairs laying multiple clutches throughout the year.

Picazuro Pigeons build their nests on forks, branches, or vine tangles, usually hidden among foliage. Most nests are placed in trees over 4 meters tall, though some were found in bushes under 3 meters. The nests are small, cup-shaped structures made of twigs, petioles, leaf veins, and sometimes lianas. The average nest height above the ground is around 4.1 meters.